Olmutinib
- Catalog NO.:A857637
- CAS No. : 1353550-13-6
- Molecular Formula:C26H26N6O2S
- Molecular Weight: 486.59
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Product Details
CAS Number | 1353550-13-6 | Appearance | Yellow solid |
Catalog Number | A857637 | MDL Number | Not available |
Molecular Formula | C26H26N6O2S | Molecular Weight | 486.59 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Olmutinib, also known as HM61713 and BI-1482694, is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). BTK is a member of the Tec family of non-receptor protein tyrosine kinases. BTK is mostly expressed in hematopoietic cells such as B cells, mast cells and macrophages. BTK plays key roles in multiple cell signaling pathways including B-Cell Receptor (BCR) and Fc receptor (FcR) signaling cascades and is an essential mediator not only in B-cell dependent but also in myeloid cell dependent inflammatory arthritis. HM71224 has been selected as a novel therapeutic agent for the treatment of autoimmune diseases such as RA. |