ODM-201

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For R&D use only.

Catalog NO.：A888821
CAS No. : 1297538-32-9
Molecular Formula：C₁₉H₁₉ClN₆O₂
Molecular Weight： 398.85

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Quality Control&SDS

SDS COA HPLC/GC NMR

Product Details

CAS Number	1297538-32-9	Appearance	Off-white powder
Catalog Number	A888821	MDL Number	MFCD29472270
Molecular Formula	C₁₉H₁₉ClN₆O₂	Molecular Weight	398.85
Boiling Point		Melting Point
Flash Point		Density
Synonyms	N-((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. ODM-201 overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.

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H200	Explosives (Unstable Explosive)
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