(R)-2-((4-(((3,4-二氢-2H-吡喃并[2,3-c]吡啶-6-基)甲基)氨基)哌啶-1-基)甲基)-1,2-二氢3H,8H-2a,5,8a-三氮杂苊烯-3,8-二酮，Gepotidacin，1075236-89-3-Amadis Chemical

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[CAS No.1075236-89-3] A857306 (R)-2-((4-(((3,4-二氢-2H-吡喃并[2,3-c]吡啶-6-基)甲基)氨基)哌啶-1-基)甲基)-1,2-二氢3H,8H-2a,5,8a-三氮杂苊烯-3,8-二酮 98%

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Catalog No.: A857306

Cas No.: 1075236-89-3

Molecular Formula: C₂₄H₂₈N₆O₃

Molecular Weight: 448.52

MDL NO: MFCD27987926

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Quality Control of [1075236-89-3]

NMR

CNMR

HPLC

LC-MS

Related Doc. of[1075236-89-3]

SDS

Specification

MOL

SDF

基础信息 [1075236-89-3]

同义词: GSK-2140944; GSK2140944;(2R)-2-[(4-{[(3,4-dihydro-2H-pyrano[2,3-c]pyridin- 6-yl)methyl]amino}piperidin-1-yl)methyl]-1,2-dihydro- 3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Appearance: Yellow powder

存储要求: Store in 2-8°C for long term (months)

沸点: 661.9±65.0 °C(Predicted)

熔点:

闪点:

Pubchem ID: 25101874

Smiles: O=C(C=NC(C=C1)=C23)N3[C@H](CN4CCC(NCC(N=C5)=CC6=C5OCCC6)CC4)CN2C1=O

InchiKey: PZFAZQUREQIODZ-LJQANCHMSA-N

Inchi: InChI=1S/C24H28N6O3/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2/t19-/m1/s1

安全信息 [1075236-89-3]

GHS Pictogram:

Signal Word: Warning

Class:

Precautionary Statements: P264;P280;P302+P352;P305+P351+P338;P332+P313;P337+P313;P362

UN No.:

Hazard Statements: H302;H315;H319;H332;H335

包装等级:

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产品详情 [1075236-89-3]

Gepotidacin, also known as GSK-2140944, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin is a novel antibacterial drug candidate. Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

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